By Lathrop R. H., Rogers Jr R. G., Smith T. F.
A rigorous Bayesian research is gifted that unifies protein sequence-structure alignment and popularity. Given a chain, specific formulae are derived to choose (1) its globally so much possible middle constitution from a constitution library; (2) its globally such a lot possible alignment to a given middle constitution; (3) its so much possible joint center constitution and alignment selected globally around the whole library; and (4) its so much possible person segments, secondary constitution, and super-secondary constructions around the whole library. The computations concerned are NP-hard within the basic case (3D-3D). quick specific recursions for the constrained series singleton-only (1D-3D) case are given. Conclusions contain: (a) the main possible joint middle constitution and alignment isn't unavoidably the main possible alignment of the main possible center constitution, yet really maximizes the made of middle and alignment possibilities; (b) use of a sequence-independent linear or affine hole penalty can result within the highest-probability threading no longer having the bottom ranking; (c) picking out the main possible center constitution from the library (core constitution choice or fold acceptance simply) comprises evaluating possibilities summed over all attainable alignments of the series to the center, and never evaluating person optimum (or near-optimal) sequence-structure alignments; and (d) assuming uninformative priors, middle constitution choice is resembling evaluating the ratio of 2 international potential.
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Extra resources for A Bayes-optimal sequence-structure theory that unifies protein sequence-structure recognition and alignment
Biol. 255, 641-665. Lawrence, C. , S. F. Altschul, M. S. Boguski, J. S. Liu, A. F. Neuwald and J. C. Wootton (1993). Detecting subtle sequence signals: a Gibbs sampling strategy for multiple alignment. Science 262, 208214. Lemer, C. , M. J. Rooman and S. J. Wodak (1995). Protein structure prediction by threading methods: Evaluation of current techniques. Proteins: Structure, Function, and Genetics 23 337-355. , J. U, Bowie and D. Eisenberg (1992). Assessment of protein models with three-dimensional profiles.
Kollman, D. A. Case, U. C. Singh, C. Ghio, G. Alagona, S. Profeta and P. Weiner (1984). A new force field for molecular mechanical simulation of nucleic acids and proteins. J. Am. Chem. Sac. 106, 765-784. , I. Muchnik and T. F. Smith (1994). Modeling protein cores with Markov random fields. Math. Biosci. 124, 149-179. White, J. , C. M. Stultz and T. F. Smith (1994). Protein classification by state-space modeling and optimal filtering of amino-acid sequences. Math. Biosci. 191, 35-75. Wilbur, W.
Brooks, C. , M. Karplus and B. M. Pettitt (1990). Proteins: A Theoretical Perspective of Dynamics, Structure, and Thermodynamics, New York: John Wiley and Sons. Bryant, S. H. and S. F. Altschul (1995). Statistics of sequence-structure threading. Current Opinion in Structural Biol. 5, 236-244. Bryant, S. H. and C. E. Lawrence (1993). An empirical energy function for threading protein sequence through the folding motif. Proteins; Structure, Function, and Genetics 16, 92-112. Crippen, G. M. (1996).